Mutp53 level is widely variable among individual cancer cells in tumor tissues, and within cells a higher level of mutp53 is usually observed in the nucleus as compared to the cytoplasm.This spatial heterogeneity in mutp53 expression has been well documented and likely plays an important role in tumor therapeutic resistance.However, its underlying
Checkpoint inhibitor therapy has emerged as an effective therapeutic strategy for many types of malignancies, especially in solid tumors.Within the last two decades, numerous monoclonal antibody drugs targeting the CTLA-4 and PD-1/PD-L1 checkpoint pathways have seen FDA approval.Within hematologic malignancies, Hodgkin Lymphoma has seen the greates
A constitutive model based on the dislocation glide and deformation twinning is adapted to face-centered cubic high-entropy alloys (HEAs) as exemplified by the CrMnFeCoNi system.In this model, the total scooters dislocation density is considered as the only internal variable, while the evolution equation describing its variation during plastic defo
Abstract Background Testicular cancer (TC) is the most common malignancy in young adult men, and in many countries the incidence rates of testicular cancer have been increasing since the middle of the twentieth century.Since disease presentation and tumor progression patterns are often heterogeneous Custom Tee across racial groups, there may be imp